一、基本情况
姓名：李广迪
职称：副教授，硕士生导师，博士生导师
学位：生物医学博士,计算机硕士，数学本科
党派：中国致公党党员，致公党湘雅医院总支委员
电话：0731-84805414
邮箱：liguangdi@csu.edu.cn,550604042@qq.com
部门：365体育官方唯一入口，365体育官方唯一入口
研究方向：医学统计学，流行病学，生物信息学，基因组学，数学建模，算法设计
二、个人学习经历
1.2009/09 — 2014/08，比利时鲁汶大学(2021泰晤士全球大学排名45位),医学院,生物医学博士
2.2010/09 — 2011/07，比利时鲁汶大学,生命科学院，化学与生物物理学进修硕士
3.2006/09 — 2009/06，山东大学，计算机科学与技术学院，计算机软件与理论硕士
4.2002/09 — 2006/06，湖南大学，数学与计量经济学院，数学与应用数学本科
5.1996/09 — 2002/06，湖南师大附中，初中和高中
三、个人工作经历
1.2018/04—至今, 365体育官方唯一入口,365体育官方唯一入口，副教授，研究生导师，博士生导师。
2.2015/01 — 2018/02，365体育官方唯一入口,湘雅二医院，副教授，研究生导师。
3.2008/03 — 2009/08，西班牙马德里理工大学UPM（西班牙重点公立大学），计算机学院，研究助理，获UPM研究生全额奖学金
四、人才计划和获奖情况
1.2020年，抗击新冠肺炎疫情“先进个人”（致公党湖南省委会）
2.2018年，入选湖南省“湖湘青年英才”
3.2017年，365体育官方唯一入口科研成果专项奖
4.2008年，第五届中国研究生数学建模竞赛，全国一等奖
五、科研基金项目
个人主持3项国家级课题，2项省级课题，2项目校级课题，及参与2项课题。
1.课题主持人，国家自然科学面上基金（批准号：31871324），HIV全基因组共进化诱导药物耐药性的生物信息学研究，600000元，2019/01–2022/12
2.课题主持人，国家自然科学面上基金（批准号：31571368），基于系统生物学的HIV全基因组蛋白交互机制研究，570000元，2016/01–2019/12
3.子课题主持人，国家自然科学重点项目（批准号：81730064），丙型肝炎病毒逃逸人肝细胞先天免疫应答而致持续感染机制，300000元，2018/01–2022/12
4.课题主持人，湖南省自然科学青年基金（批准号：2018JJ3713），HIV Gag基因突变诱导蛋白酶抑制剂抗药性的系统生物学研究，50000元，2018/01–2020/12
5.课题主持人，湖南省湖湘青年英才基金，500000元，2019/01–2021/12
6.课题主持人，365体育官方唯一入口人才引进基金资助项目，800000元，2019/01–2021/12
7.课题主持人，365体育官方唯一入口“创新驱动计划”人才基金（批准号：2016CX031），600000元，2016/01–2017/12
8.课题骨干（排名第二），中国科学技术部国家重点研发计划（项目批准号：2016YFC1305001），1型糖尿病的遗传与免疫学发病机制研究，7000000元，2016/10 – 2021/10.
9.课题骨干（排名第三），365体育官方唯一入口理、工、医学科医学科战略先导专项（项目批准号：ZLXD2016003），免疫代谢在糖尿病早期预警、诊断干中的作用及治疗，20000000元，2016/12 – 2020/12.
六、SCI期刊论文
发表40余篇SCI论文，其中第一或通讯作者论文>20篇（影响因子合计>200，引用>2500次数）
Guangdi Li*,Erik De Clercq*, Therapeutic options for the 2019 novel coronavirus (2019-nCoV),Nature Reviews Drug Discovery. 2020,March;19(3):149-150（第一作者，影响因子：84.69，引用次数>1000）
Guangdi Li, Yali Wang*, Erik De Clercq*, Approved HIV reverse transcriptase inhibitors in the past decade, Acta Pharmaceutica Sinica B, 2021 (第一作者，影响因子：11.614，JCR一区)
Guangdi Li, Erik De Clercq*,A medicinal chemist who reshaped the antiviral drug industry , Medicinal Research Reviews,2022 Mar;42(2):647-653 (第一作者，影响因子：12.944，JCR一区)
Xixi Jing #, Min Xu #, Deye Song#, Tingting Yue, Yali Wang, Pan Zhang, Yanjun Zhong, Min Zhang, Tommy Tsan-Yuk Lam, Nuno Rodrigues Faria, Erik De Clercq, Guangdi Li*, Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19, Immunity & Ageing, 2022（唯一通讯作者，JCR一区，影响因子6.4）
Miao Miao, Erik De Clercq, Guangdi Li*. Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective, Biomedicines 2021, 9, 412 (唯一通讯作者，影响因子：6.05，JCR一区)
Guangdi Li, Ming Xu, Tingting Yue, Weijie Gu, and Li Tan*, Life-long Passion for Antiviral Research and Teaching: 80th Anniversary of Prof. Dr. Erik De Clercq, Biochemical Pharmacology, 2021 Feb 19;185:114485 (第一作者，影响因子：5.96，JCR一区)
Guangdi Li, Tingting Yue, Pan Zhang, Weijie Gu, Ling-Jie Gao, and Li Tan*, Drug Discovery of Nucleos(t)ide Antiviral Agents, Molecules, 2021 Feb 9;26(4):923 (第一作者，影响因子：4.14，JCR二区)
Chuanhao Jiang, Yali Wang, Min Hu, Lingjun Wen, Chuan Wen, Yang Wang, Weihong Zhu, Shi Tai, Zhongbiao Jiang, Kui Xiao, Nuno Rodrigues Faria, Erik De Clercq, Junmei Xu, Guangdi Li*. Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical & Translational Immunology.2020 Sep 26;9(9):e1182 (唯一通讯作者，影响因子：6.16)
Guangdi Li, Yacong Liu, Xixi Jing, Yali Wang, Miao Miao, Li Tao, Zhiguo Zhou, Yuanlin Xie, Yaxiong Huang, Jianhua Lei, Guozhong Gong, Ping Jin, Yuantao Hao, Nuno Rodrigues Faria, Erik De Clercq, Min Zhang*. Mortality risk of COVID-19 in elderly males with comorbidities: A multi-country study, Aging. 2020 Dec 31;13(1):27-60 (第一作者，影响因子：5.68，JCR一区)
Zhiguo Zhou†, Min Zhang†, Yali Wang†, Fang Zheng, Yaxiong Huang, Kang Huang, Qizhi Yu, Chunlin Cai, Dong Chen, Yi Tian, Jianhua Lei, Xinqiang Xiao, Erik De Clercq,Guangdi Li*,Yuanlin Xie*, Guozhong Gong*, Clinical characteristics of older and younger patients infected with SARS-CoV-2, Aging. 202012(12):11296-11305 (共同通讯作者，影响因子：5.68，JCR一区)
Miao Miao, Xixi Jing, Erik De Clercq,Guangdi Li*, Danoprevir for the Treatment of Hepatitis C Virus Infection, Drug Design, Development and Therapy, 2020 July:14: 2759-2774 (唯一通讯作者，影响因子：4.16，JCR二区)
Miao Miao, Erik De Clercq,Guangdi Li*, Clinical significance of chemokine receptor antagonists, Expert Opinion on Drug Metabolism & Toxicology, 2020 Jan;16(1):11-30（唯一通讯作者, 影响因子：4.48，JCR二区）
Min Zhang†,Guangdi Li†,Jia Shang, Chen Pan, Minxiang Zhang, Zhibiao Yin 6, Qing Xie, Yanzhong Peng, Qing Mao, Xinqiang Xiao, Yongfang Jiang1, Kaizhong Luo1, Yun Xu, Hai Ding, Wenzhou Fan, Vidaurre Diego, MahmoudReza Pourkarim, Erik De Clercq, Guiqiang Wang*, Guozhong Gong*, Rapidly decreased HBV RNA predicts responses of pegylated interferons in HBeAg-positive patients: a longitudinal cohort study, Hepatology International, 2020，14(2):212-2242020 (共同第一作者，影响因子:6.05)
Yali Wang, Erik De Clercq,Guangdi Li*,Current and emerging non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV-1 treatment, Expert Opinion on Drug Metabolism & Toxicology, 15(10):813-829, 2019（唯一通讯作者，影响因子：3.487，JCR二区）
Erik De Clercq,Guangdi Li*，Approved Antiviral Drugs over the Past 50 Years，Clinical Microbiology Reviews. Jul;29(3):695-747, 2016（共同通讯作者，影响因子：19.96， 被评为期刊封面论文，入选前0.1% ESI千分之一热点论文，JCR一区）
Guangdi Li*, Erik De Clercq*, HIV Genome-Wide Protein Associations: a Review of 30 Years of Research, Microbiology and Molecular Biology Reviews. 80(3):679-731, 2016（第一作者，影响因子14.6，期刊封面，JCR一区）
Guangdi Li*, Erik De Clercq*, Current therapy for chronic hepatitis C: The role of direct-acting antivirals, Antiviral Research. 24;142:83-122, 2017（第一作者，影响因子：4.307，期刊封面论文，入选前1% ESI高频引用论文）
Guangdi Li, Kristof Theys, Jens Verheyen, Andrea-Clemencia Pineda-Peña, Ricardo Khouri, Supinya Piampongsant, Mónica Eusébio, Jan Ramon, Anne-Mieke Vandamme. A new ensemble coevolution system for detecting HIV-1 protein coevolution. Biology Direct, 10:1, 2015 (第一作者，影响因子: 4.04， JCR二区)
Guangdi Li, Supinya Piampongsant, Nuno Rodrigues Faria, Arnout Voet, Andrea-Clemencia Pineda-Peña, Ricardo Khouri, Philippe Lemey, Anne-Mieke Vandamme, Kristof Theys. An integrated map of HIV genome-wide diversity from a population perspective. Retrovirology, 12:18, 2015 (第一作者，影响因子: 3.99， JCR二区)
Guangdi Li, Jens Verheyen, Kristof Theys, Supinya Piampongsant, Kristel Van Laethem, Anne-Mieke Vandamme. HIV-1 Gag C-terminal amino acid substitutions emerging under selective pressure of protease inhibitors in patient populations infected with different HIV-1 subtypes. Retrovirology, 11:79, 2014 (第一作者，影响因子: 4.19， JCR一区)
Guangdi Li, Jens Verheyen, Soo-Yon Rhee, Arnout Voet, Anne-Mieke Vandamme, Kristof Theys, Functional conservation of HIV-1 Gag: implications for rational drug design. Retrovirology 10(1):126. 2013 (第一作者，影响因子: 5.66)
Lize Cuypers†,Guangdi Li†, Christoph Neumann-Haefelin, Supinya Piampongsant, Pieter Libin, Kristel Van Laethem, Anne-Mieke Vandamme and Kristof Theys. Mapping the genomic diversity of HCV subtypes 1a and 1b: Implications of structural and immunological constraints for vaccine and drug development. Virus Evolution, 2(2): vew024, 2016 (共同第一，影响因子: 5.4， JCR一区)
Xiaozhou Li#, Jian Pan#, Huiling Li, Guangdi Li, Bohao Liu, Xianming Tang, Xiangfeng Liu, Zhibiao He, Zhenyu Peng, Hongliang Zhang, Luxiang Wang, Yijian Li, Xudong Xiang, Xiangping Chai, Yunchang Yuan, Peilin Zheng, Dongshan Zhang*，DsbA-L interacts with VDAC1 in mitochondrion-mediated tubular cell apoptosis and contributes to the progression of acute kidney disease，EBioMedicine . 2022 Feb 3;76:103859（合作作者，JCR一区，影响因子8.14）
William Marciel de Souza, Lewis Fletcher Buss, Darlan da Silva Candido, Jean-Paul Carrera, Sabrina Li, Alexander E. Zarebski, Rafael Henrique Moraes Pereira, Carlos A. Prete Jr, Andreza Aruska de Souza-Santos, Kris V. Parag, Maria Carolina T. D. Belotti, Maria F. Vincenti-Gonzalez, Janey Messina, Flavia Cristina da Silva Sales, Pamela dos Santos Andrade, Vítor Heloiz Nascimento, Fabio Ghilardi, Leandro Abade, Bernardo Gutierrez, Moritz U. G. Kraemer, Carlos K. V. Braga, Renato Santana Aguiar, Neal Alexander, Philippe Mayaud, Oliver J. Brady, Izabel Marcilio, Nelson Gouveia, Guangdi Li, Adriana Tami, Silvano Barbosa de Oliveira, Victor Bertollo Gomes Porto , Fabiana Ganem, Walquiria Aparecida Ferreira de Almeida, Francieli Fontana Sutile Tardetti Fantinato, Eduardo Marques Macário, Wanderson Kleber de Oliveira, Mauricio L. Nogueira, Oliver G. Pybus, Chieh-Hsi Wu, Julio Croda, Ester C. Sabino, and Nuno Rodrigues Faria. Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil. Nat Hum Behav. 2020 Aug;4(8):856-65. PMID: 32737472. doi: 10.1038/s41562-020-0928-4. (合作作者，影响因子：12.282， JCR一区)
Xiaozhou Li, Jian Pan, Huiling Li, Guangdi Li, Xiangfeng Liu, Bohao Liu, Zhibiao He, Zhengyu Peng, Hongliang Zhang, Yijian Li, Xudong Xiang, Xiangping Chai, Yunchang Yuan, Peilin Zheng, Feng Liu, Dongshan Zhang. DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice. Nat Commun. 2020 Sep 18;11(1):4467 (合作作者，影响因子：12.121， JCR一区)
Sai-Qun Luo, De-Hui Xiong, Jiang Li, Guangdi Li, Yali Wang, Jia-Ming Zhang, Xiu-Fen Bu, Wei-Xin Hu, Jingping Hu, C1orf35 contributes to tumorigenesis by activating c-MYC transcription in multiple myeloma. Oncogene. 2020 Apr;39(16):3354-66. (合作作者，影响因子：7.971， JCR一区)
Rilin Deng, Chaohui Zuo, Yongqi Li, Binbin Xue, Zhen Xun, Yanxia Guo, Xiaohong Wang, Yan Xu, Renyun Tian, Shengwen Chen, Qian Liu, Jinwen Chen, Jingjing Wang, Xiang Huang, Huiyi Li, Mengmeng Guo, Xintao Wang, Miaomiao Yang, Zhihui Wu, Jinfeng Wang, Jiahuan Ma, Jun Hu, Guangdi Li, Songqing Tang, Zhengkun Tu, Hongbin Ji, and Haizhen Zhu, The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway. Cellular & Molecular Immunology, 2020 Nov;17(11):1163-1179 (合作作者，影响因子：8.484， JCR一区)
Qian Li, Yifan Wang, Weijuan Jia, Heran Deng, Guangdi Li, Weiye Deng, Jiewen Chen, Betty Y S Kim, Wen Jiang, Qiang Liu, Jieqiong Liu, Low-Dose Anti-Angiogenic Therapy Sensitizes Breast Cancer to PD-1 Blockade. Clin Cancer Res. 2020 Apr 1;26(7):1712-24. (合作作者，影响因子：10.107， JCR一区)
Qinya Xie, Shengwen Chen, Renyun Tian, Xiang Huang, Rilin Deng, Binbin Xue, Yuwen Qin, Yan Xu, Jingjing Wang, Mengmeng Guo, Jinwen Chen, Songqing Tang, Guangdi Li, Haizhen Zhu, Long Noncoding RNA ITPRIP-1 Positively Regulates the Innate Immune Response through Promotion of Oligomerization and Activation of MDA5, Journal of Virology, 2018 Aug 16;92(17). pii: e00507-18 (合作作者，影响因子：4.368，JCR一区)
Binbin Xue, Huiyi Li, Mengmeng Guo, Jingjing Wang, Yan Xu, Xuan Zou, Rilin Deng, Darong Yang, Guangdi Li, Haizhen Zhu. TRIM21 promotes innate immune response through Lys27-linked poly-ubiquitination of MAVS, Journal of Virology, 2018 Jun 29;92(14):e00321-18 (合作作者，影响因子：4.368， JCR一区)
Yuwen Qin, Binbin Xue, Chunyan liu, Xiaohong Wang, Renyun Tian, Qinya Xie, Mengmeng Guo, Guangdi Li, Darong Yang, and Haizhen Zhu. NLRX1 mediates MAVS degradation to attenuate hepatitis C virus-induced innate immune response through PCBP2.Journal of Virology, 91:23 e01264-17, 2017 (合作作者，影响因子：4.663，JCR一区)
Steven Sijmons, Kim Thys, Mirabeau Mbong Ngwese, Ellen Van Damme, Jan Dvorak, Marnix Van Loock, Guangdi Li, Ruth Tachezy, Laurent Busson, Jeroen Aerssens, Marc Van Ranst and Piet Maes. High-Throughput Analysis of Human Cytomegalovirus Genome Diversity Highlights the Widespread Occurrence of Gene-Disrupting Mutations and Pervasive Recombination, Journal of Virology, 89(15):7673–7695, 2015 (合作作者，影响因子: 4.7，JCR一区)
Linyun He, Mowei Tang, Ting Xiao, Hailan Liu, Wei Liu, Guangdi Li, Feng Zhang, Yalun Xiao, Zhiguang Zhou, Feng Liu1, Fang Hu. Obesity Associated miR-199a/214 Cluster Inhibits Adipose Browning via PRDM16-PGC-1α Transcriptional Network. Diabetes. 2018 Dec;67(12):2585-2600 (合作作者，影响因子：7.273， JCR一区)
Wen Meng, Xiuci Liang, Hongzhi Chen, Hairong Luo, Juli Bai, Guangdi Li, Qinghai Zhang, Ting Xiao, Sijia He, Yacheng Zhang, Zhipeng Xu, Bo Xiao, Fang Hu, and Feng Liu, Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway, Diabetes, 66(5):1196-1213, 2017 (合作作者，影响因子: 8.7，JCR一区)
Ahmed A Al-Qahtani, Mahmoud Reza Pourkarim, Nídia Sequeira Trovão, Valentijn Vergote, Guangdi Li, Marijn Thijssen, Ayman A Abdo, Faisal M Sanai, Damian Dela Cruz, Marie Fe F Bohol, Mashael R Al-Anazi, Mohammed N Al-Ahdal，Molecular epidemiology, phylogenetic analysis and genotype distribution of hepatitis B virus in Saudi Arabia: Predominance of genotype D1. Infect Genet Evol. 2020 Jan;77:104051. PMID: 31634640. doi: 10.1016/j.meegid.2019.104051 (合作作者，影响因子：2.773， JCR三区).
Andrea-Clemencia Pineda-Peña, Marta Pingarilho, Guangdi Li, Bram Vrancken, Pieter Libin, Perpétua Gomes, Ricardo Jorge Camacho, Kristof Theys, Ana Barroso Abecasis, Portuguese HIV-1 Resistance Study Group, Drivers of HIV-1 transmission: The Portuguese case. PLoS One. 2019;14(9):e0218226. (合作作者，影响因子：2.74,JCR三区)
Meizhu Liu, Lingxiang Wu, Weijing Wu, Guangdi Li, Taisheng Cai, Jiaxi Liu. The relationships among verbal ability, executive function, and theory of mind in young children with cochlear implants. International journal of audiology, 2018 Dec;57(12):875-882 (合作作者，影响因子：1.759,JCR三区)
Li Tan, Le Bai, Ling Wang, Lagu He, Guangdi Li, Wenhan Du, Ting Shen, Zheyi Xiang, Jiali Wu, Zhonghua Liu, Min Hu. Antifungal activity of spider venom-derived peptide lycosin-I against Candida tropicalis. Microbiological Research. 2018 Nov;216:120-128. (合作作者，影响因子：2.777,JCR二区)
Zhuoying Liu, Ting Xiao, Guangdi Li, Fang Hu. APPL, More Than Just Adiponectin Receptor Binding Proteins. Cellular Signalling, 32:76-84, 2017 (合作作者，影响因子: 4.2,JCR一区)
Lize Cuypers, Francesca Ceccherini Silberstein, Kristel Van Laethem, Guangdi Li, Anne-Mieke Vandamme, Jürgen Kurt Rockstroh. Impact of HCV genotype on treatment regimens and drug resistance: a snapshot in time: HCV genotyping for treatment and drug resistance, Reviews in Medical Virology, Nov;26(6):408-434, 2016 (合作作者，影响因子: 4.5,JCR一区)
Steven Sijmons, Kim Thys, Mirabeau Mbong Ngwese, Ellen Van Damme, Jan Dvorak, Marnix Van Loock, Guangdi Li, Ruth Tachezy, Laurent Busson, Jeroen Aerssens, Marc Van Ranst and Piet Maes. High-Throughput Analysis of Human Cytomegalovirus Genome Diversity Highlights the Widespread Occurrence of Gene-Disrupting Mutations and Pervasive Recombination, Journal of Virology, 89(15):7673–7695, 2015 (合作作者，影响因子: 4.7)
Andrea-Clemencia Pineda, Nuno Rodrigues Faria, Francisco-Javier Diaz, Patricia Olaya, Casper Møller Frederiksen, Guangdi Li, Arley Gomez-Lopez, Philippe Lemey, Anne-Mieke Vandamme. Trends and Predictors of Transmitted Drug Resistance (TDR) and Clusters with TDR in a Local Belgian HIV-1 Epidemic. PLOS One, PLoS ONE 01; 9(7):e101738, 2014 (合作作者，影响因子: 3.51)
Sarah Megens, Dolores Vaira, Greet De Baets, Nathalie Dekeersmaeker, Yoeri Schrooten, Guangdi Li, Joost Schymkowitz, Frederic Rousseau, Anne-Mieke Vandamme, Michel Moutschen, Kristel Van Laethem. Horizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits, Virology, 456:310–318, 2014 (合作作者，影响因子: 3.27)
Eline Boons, Guangdi Li, Els Vanstreels, Thomas Vercruysse, Christophe Pannecouque, Anne-Mieke Vandamme, Dirk Daelemans. A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity. Antiviral Research, 12, 91-102, 2014 (合作作者，影响因子: 3.43)
七、指导本科生大创课题
1. 陶李，曾诗琴，傅兰乔，黄涵宁，朱湘郡，基于ELES模型的新冠肺炎疫情下大学生消费结构的分析，2020年，省级课题， 资助：10000元，课题指导老师
2. 陈昊章，扎西普赤，陈颖昕，时顺一，疫情背景下大学生网课学习情况数据挖掘及对策分析，2020年，省级课题，资助：10000元，课题指导老师
八、著作
1.《医学统计学》第五版-第41章R语言，人民卫生出版社，2020年
2.《 Encyclopedia of Virology, Fourth Edition》- Volume 4-Chapter 1: Antiviral Classification, 出版社: Academic Press, 2021年
九、社会兼职
网络教学：
1.雅医英语公众号（微信名：xymedicine），创始人
2.生物医学计算平台（www.virusface.com），创始人
期刊编委会：
1.《Pharmaceutics》，影响因子：4.42
期刊审稿人：
《BMC Bioinformatics》，《Science Advances》, 《Nature Communication》, 《Clinical infectious Diseases》, 《Frontiers in Genetics》, 《Pharmaceutics》，《Viruses》, 《Journal of Infection and Public Health》, 《Journal of Medical Virology》，《Virology》，《Journal of Medical Virology》等SCI期刊。
学会：
1.湖南省医学教育科技学会公共卫生与预防医学教育专业委员会委员
2.湖南省康复医学会临床护理心理康复学会副组长
3.国际抗病毒研究组织委员
十、研究生招生方向
欢迎优秀学生报考我的硕士和博士，丰厚的助研津贴，推荐国外留学和交流：
1.流行病与卫生统计学（代码：100401）
2. 生物统计(代码：0710Z1）
